Prevalence of multi-drug resistance Mycobacterium tuberculosis in world population: Systematic review and meta-analysis

AbstractBackgroundDrug resistance is the major problem in tuberculosis (TB) treatment and control. In the present study, it was decided to consider the prevalence and distribution of multi-drug resistance Mycobacterium tuberculosis (MDR-TB) in Iran using meta-analysis based on systematic review of articles published, which will provide more detailed information to clearly overview the status of TB.MethodsAll original articles published in literature database including PubMed, Sciencedirect, Web of Science, Google Scholar, Biological abs, Iranmedex, and SID systematically reviewed the prevalence of MDR-TB. The summarized data has been analyzed statistically.ResultsFinal analyses included 39 samples that have been selected from 535 studies. Overall MDR-TB prevalence in Iran was estimated to be 0.15 (95% CI=0.14–0.16). Corresponding estimates by city were Mashhad 0.22 (95% CI=0.18–0.27), Tehran 0.16 (95% CI=0.15–0.17), and Zahedan 0.10 (95% CI=0.07–0.15). In 2003 there was a high report of MDR-TB 0.88 (95% CI=0.75–0.96).ConclusionsAccording to the results, prevalence of MDR-TB in Iran is lower than worldwide WHO report. Effective control program is needed in order to control and eradicate the spread of drug resistance strains