Myocardial amiodarone and desethylamiodarone concentrations were measured at multiple sites in the explanted heart in four patients who underwent cardiac transplantation. Patients were taking amiodarone, 200 to 400 mg/day (mean 300 ± 115), for 88 to 428 days (mean 229 ± 148). The mean cumulative dose was 58 ± 21.3 g. Plasma amiodarone concentration in three subjects was 204, 312 and 419 ng/ml and desethylamiodarone concentration was 268, 513 and 880 ng/ml, respectively.Significant interindividual variability in myocardial concentrations of amiodarone and desethylamiodarone was observed (p < 0.05). Mean myocardial amiodarone concentration ranged from 4 ± 1.0 to 29 ± 17.2 μg/g (p < 0.05); mean desethylamiodarone concentration ranged fro...
ObjectiveClinical studies have demonstrated the efficacy of oral and intravenous amiodarone therapy ...
Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with unpredictable pharma...
AbstractAlthough amiodarone is an effective drug for the treatment of life-threatening ventricular a...
Myocardial amiodarone and desethylamiodarone concentrations were measured at multiple sites in the e...
The time to onset of action of amiodarone is often long in patients treated for arrhythmias; one rea...
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardia...
Because the value of monitoring amiodarone plasma concentrations remains undefined, this study was p...
Amiodarone is a potent antiarrhythmic agent that is effective in controlling both atrial and ventric...
AbstractObjective. The purpose of this study was to use invasive monitoring to analyze the hemodynam...
To assess and compare the hemodynamic profile of short-and long-term amiodarone administration in th...
The relationship of apparent steady-state serum concentrations of amiodarone and its metabolite, des...
The mechanisms of action of the potent antiarrhythmic drug amiodarone are unknown. However, amiodaro...
AbstractObjectives. The present work was designed to test the effects of amiodarone therapy on actio...
SUMMARY While the antiarrhythmic effects of amiodarone are well-documented, its hemodynamic effects ...
A major disadvantage of conventional amiodarone therapy is the long delay between initiation of ther...
ObjectiveClinical studies have demonstrated the efficacy of oral and intravenous amiodarone therapy ...
Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with unpredictable pharma...
AbstractAlthough amiodarone is an effective drug for the treatment of life-threatening ventricular a...
Myocardial amiodarone and desethylamiodarone concentrations were measured at multiple sites in the e...
The time to onset of action of amiodarone is often long in patients treated for arrhythmias; one rea...
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardia...
Because the value of monitoring amiodarone plasma concentrations remains undefined, this study was p...
Amiodarone is a potent antiarrhythmic agent that is effective in controlling both atrial and ventric...
AbstractObjective. The purpose of this study was to use invasive monitoring to analyze the hemodynam...
To assess and compare the hemodynamic profile of short-and long-term amiodarone administration in th...
The relationship of apparent steady-state serum concentrations of amiodarone and its metabolite, des...
The mechanisms of action of the potent antiarrhythmic drug amiodarone are unknown. However, amiodaro...
AbstractObjectives. The present work was designed to test the effects of amiodarone therapy on actio...
SUMMARY While the antiarrhythmic effects of amiodarone are well-documented, its hemodynamic effects ...
A major disadvantage of conventional amiodarone therapy is the long delay between initiation of ther...
ObjectiveClinical studies have demonstrated the efficacy of oral and intravenous amiodarone therapy ...
Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with unpredictable pharma...
AbstractAlthough amiodarone is an effective drug for the treatment of life-threatening ventricular a...