Diabetes mellitus disrupts all phases of the wound repair cascade and leads to development of chronic wounds. We previously showed that topical erythropoietin (EPO) can promote wound repair in diabetic rats. Fibronectin (FN) has a critical role throughout the process of wound healing, yet it is deficient in wound tissues of diabetic patients. Therefore, we investigated the effect of topical treatment of both EPO and FN (EPO/FN) on wound repair in diabetic mice. Full-thickness excisional skin wounds in diabetic and nondiabetic mice were treated with a cream containing vehicle, EPO, FN, or EPO/FN. We assessed the rate of wound closure, angiogenesis, apoptosis, and expression of inflammatory cytokines, endothelial nitric oxide synthase (eNOS) ...
Background: Wound healing is impaired in diabetes mellitus, but the mechanisms involved in this proc...
International audiencePressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular...
This thesis focuses on the diabetic condition at the cellular level, and how this may lead to late c...
Diabetes mellitus disrupts all phases of the wound repair cascade and leads to development of chroni...
Wound healing in diabetic patients is slower than in healthy individuals. Erythropoietin (EPO) has n...
Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired a...
The effects of recombinant human erythropoietin (rHuEPO) in diabetes-related healing defects were in...
Erythropoietin exerts hematopoietic effects by stimulating proliferation of early erythroid precurso...
Epoxyeicosatrienoic acids (EET) facilitate regeneration in different tissues, and their benefit in d...
Objective., Erythropoietin interacts with vascular endothelial growth factor (VEGF) and stimulates e...
Erythropoietin (EPO) is a type I cytokine that utilizes different receptor isoforms either to mainta...
Wound healing is a complicated biological process that involves interactions of multiple cell types,...
Pressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular (C-fiber/endothelium)...
Results of in vivo studies have shown erythropoietin (EPO) is associated with anti-inflammatory, ant...
Experimental models for chronic skin lesions are excision and pressure ulcer, defined as "open" and ...
Background: Wound healing is impaired in diabetes mellitus, but the mechanisms involved in this proc...
International audiencePressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular...
This thesis focuses on the diabetic condition at the cellular level, and how this may lead to late c...
Diabetes mellitus disrupts all phases of the wound repair cascade and leads to development of chroni...
Wound healing in diabetic patients is slower than in healthy individuals. Erythropoietin (EPO) has n...
Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired a...
The effects of recombinant human erythropoietin (rHuEPO) in diabetes-related healing defects were in...
Erythropoietin exerts hematopoietic effects by stimulating proliferation of early erythroid precurso...
Epoxyeicosatrienoic acids (EET) facilitate regeneration in different tissues, and their benefit in d...
Objective., Erythropoietin interacts with vascular endothelial growth factor (VEGF) and stimulates e...
Erythropoietin (EPO) is a type I cytokine that utilizes different receptor isoforms either to mainta...
Wound healing is a complicated biological process that involves interactions of multiple cell types,...
Pressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular (C-fiber/endothelium)...
Results of in vivo studies have shown erythropoietin (EPO) is associated with anti-inflammatory, ant...
Experimental models for chronic skin lesions are excision and pressure ulcer, defined as "open" and ...
Background: Wound healing is impaired in diabetes mellitus, but the mechanisms involved in this proc...
International audiencePressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular...
This thesis focuses on the diabetic condition at the cellular level, and how this may lead to late c...