Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the importance of sterol balance for healthy life. Magner et al. (2013) now show that, in C. elegans, the nuclear receptor NHR-8 is key in regulation of cholesterol balance and production of dafachronic acid, a bile acid-like steroid that controls longevity
Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and pero...
C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which s...
<div><p>Mammalian nuclear receptors broadly influence metabolic fitness and serve as popular targets...
Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the impo...
Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the impo...
SummaryHormone-gated nuclear receptors (NRs) are conserved transcriptional regulators of metabolism,...
Hormone-gated nuclear receptors (NRs) are conserved transcriptional regulators of metabolism, reprod...
Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest ...
In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nucle...
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means t...
<div><p>Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel...
Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through st...
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means t...
Reproduction and aging are two processes that seem to be closely intertwined. Experiments in Caenorh...
Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and pero...
Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and pero...
C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which s...
<div><p>Mammalian nuclear receptors broadly influence metabolic fitness and serve as popular targets...
Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the impo...
Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the impo...
SummaryHormone-gated nuclear receptors (NRs) are conserved transcriptional regulators of metabolism,...
Hormone-gated nuclear receptors (NRs) are conserved transcriptional regulators of metabolism, reprod...
Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest ...
In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nucle...
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means t...
<div><p>Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel...
Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through st...
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means t...
Reproduction and aging are two processes that seem to be closely intertwined. Experiments in Caenorh...
Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and pero...
Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and pero...
C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which s...
<div><p>Mammalian nuclear receptors broadly influence metabolic fitness and serve as popular targets...