AbstractPrimary neonatal Th1 cells develop alongside of Th2 upon priming of the newborn but undergo apoptosis upon recall with antigen. These Th1 cells were isolated, and their death was correlated with elevated IL-13Rα1 chain expression. Strikingly, neutralization of Th2s′ IL-4 reduced apoptosis, sustained recall responses, and the live Th1 cells displayed a decrease in IL-13Rα1 expression. Blockade of IL-13Rα1 or IL-4Rα also restores recall and secondary Th1 responses. Adult T cells primed within the neonatal environment did not upregulate IL-13Rα1 chain or undergo apoptosis and developed recall Th1 responses. These observations indicate that developmental expression of IL-13Rα1 along with IL-4Rα provides a receptor through which IL-4 ind...
International audienceThe elicitation of T-helper type 1 (Th1) cellular immunity to eradicate intrac...
Aims: Neonatal immunity is functionally immature and skewed towards a TH2-driven, anti-inflammatory ...
The mechanisms by which T lymphocytes acquire the capacity to produce interleukin 4 (IL-4) and other...
AbstractPrimary neonatal Th1 cells develop alongside of Th2 upon priming of the newborn but undergo ...
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appe...
Neonatal immune responses are typically deficient against a wide variety of antigens, including allo...
It is known that neonates are highly susceptible to microbial infections and allergic reactions. Thi...
Immune responses in murine neonates are typically Th2-biased. This is characterized by high-level IL...
SummaryThe susceptibility to infections and the strong Th2 bias observed in neonates are thought to ...
Abstract only availableEach year approximately 1.44 million newborns worldwide die from infections d...
Title from PDF of title page (University of Missouri--Columbia, viewed on March 11, 2013).The entire...
open9noBackground. The neonatal immune system is not fully developed at birth; newborns have adequat...
Neonatal injection of semiallogeneic cells is known to promote differentiation of donor-specific CD4...
Neonates have a weakened immune system that could be due to low exposure to pathogens resulting in l...
AbstractThe relative immaturity of the neonatal immune system limits CD4+ Th1 and cytotoxic T lympho...
International audienceThe elicitation of T-helper type 1 (Th1) cellular immunity to eradicate intrac...
Aims: Neonatal immunity is functionally immature and skewed towards a TH2-driven, anti-inflammatory ...
The mechanisms by which T lymphocytes acquire the capacity to produce interleukin 4 (IL-4) and other...
AbstractPrimary neonatal Th1 cells develop alongside of Th2 upon priming of the newborn but undergo ...
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appe...
Neonatal immune responses are typically deficient against a wide variety of antigens, including allo...
It is known that neonates are highly susceptible to microbial infections and allergic reactions. Thi...
Immune responses in murine neonates are typically Th2-biased. This is characterized by high-level IL...
SummaryThe susceptibility to infections and the strong Th2 bias observed in neonates are thought to ...
Abstract only availableEach year approximately 1.44 million newborns worldwide die from infections d...
Title from PDF of title page (University of Missouri--Columbia, viewed on March 11, 2013).The entire...
open9noBackground. The neonatal immune system is not fully developed at birth; newborns have adequat...
Neonatal injection of semiallogeneic cells is known to promote differentiation of donor-specific CD4...
Neonates have a weakened immune system that could be due to low exposure to pathogens resulting in l...
AbstractThe relative immaturity of the neonatal immune system limits CD4+ Th1 and cytotoxic T lympho...
International audienceThe elicitation of T-helper type 1 (Th1) cellular immunity to eradicate intrac...
Aims: Neonatal immunity is functionally immature and skewed towards a TH2-driven, anti-inflammatory ...
The mechanisms by which T lymphocytes acquire the capacity to produce interleukin 4 (IL-4) and other...