Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation

AbstractBackground and objectiveThe number of infused CD34+cells (CD34+i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+i, ALC and prognosis in this patients.Patients and methodMedical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed.ResultsWe found significant and inversely proportional relationship between the CD34+i and the days required to reach ALC≥500/μl according to the regression line: days=−0.981×number of CD34+i+18.09.ConclusionsWe have obtained a predictive model of lymphocyte recovery based recovery of CD34+i