Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
The discovery of a new mode of telomerase minus survival, ‘HAATI’, shook the dogma that canonical te...
Linear chromosomes lose terminal sequence with every cell division due to incomplete replication by ...
In an article published in this issue of Developmental Cell, Maria Blasco's group shows that the tel...
Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point...
SummaryTelomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal...
Human chromosome ends are capped by shelterin, a protein complex that protects the natural ends from...
Eukaryotic cells must overcome two major biological problems associated with linear chromosomes: the...
Telomerase activity allows normal cells to achieve immortality, which is one of the hallmarks of can...
Telomeres are nucleoprotein complexes that cap the ends of linear chromosomes and preserve genomic i...
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere ...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
Telomerase is a cellular reverse transcriptase that adds tracts of telomeric DNA to the ends of line...
The ends of linear chromosomes are composed of repetitive hexameric sequences called telomeres. Beca...
Chromosome fragmentation is a hallmark of apoptosis, conserved in diverse organisms. In mammals, cas...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
The discovery of a new mode of telomerase minus survival, ‘HAATI’, shook the dogma that canonical te...
Linear chromosomes lose terminal sequence with every cell division due to incomplete replication by ...
In an article published in this issue of Developmental Cell, Maria Blasco's group shows that the tel...
Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point...
SummaryTelomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal...
Human chromosome ends are capped by shelterin, a protein complex that protects the natural ends from...
Eukaryotic cells must overcome two major biological problems associated with linear chromosomes: the...
Telomerase activity allows normal cells to achieve immortality, which is one of the hallmarks of can...
Telomeres are nucleoprotein complexes that cap the ends of linear chromosomes and preserve genomic i...
Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere ...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
Telomerase is a cellular reverse transcriptase that adds tracts of telomeric DNA to the ends of line...
The ends of linear chromosomes are composed of repetitive hexameric sequences called telomeres. Beca...
Chromosome fragmentation is a hallmark of apoptosis, conserved in diverse organisms. In mammals, cas...
Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cance...
The discovery of a new mode of telomerase minus survival, ‘HAATI’, shook the dogma that canonical te...
Linear chromosomes lose terminal sequence with every cell division due to incomplete replication by ...
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