SummaryDamaged and superfluous mitochondria are removed from the cell by selective autophagy, a process termed mitophagy. This serves to maintain the proper quantity and quality of the organelle. Mitophagy is executed by an evolutionarily conserved pathway, many components of which were first discovered and characterized in yeast. In a systematic screen of a yeast deletion collection, we identified ERMES, a complex connecting mitochondria and the endoplasmic reticulum (ER), as an important factor contributing to the selective degradation of mitochondria. We show that efficient mitophagy depends on mitochondrial ER tethering. ERMES colocalizes with sites of mitophagosome biogenesis and affects the formation of the isolation membrane that eng...
In this issue of Developmental Cell, Elbaz-Alon et al. (2014) and Hönscher et al. (2014) describe a ...
Mitophagy, the selective degradation of mitochondria by autophagy, is implicated in the clearance of...
Mitophagy, the selective degradation of mitochondria by autophagy, is implicated in the clearance of...
SummaryDamaged and superfluous mitochondria are removed from the cell by selective autophagy, a proc...
AbstractMitochondria autophagy (mitophagy) is a process that selectively degrades mitochondria via a...
AbstractSelective degradation of mitochondria is a fundamental process that depends on formation of ...
AbstractMitochondria autophagy (mitophagy) is a process that selectively degrades mitochondria via a...
SummaryCellular life depends on continuous transport of lipids and small molecules between mitochond...
Mitochondria are critical for supplying energy to the cell, but during catabolism this organelle als...
Mitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regu...
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by...
The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an importa...
Eukaryotic cells rely on autophagy to degrade damaged or excess proteins and organelles. Autophagy c...
SummaryA new study uncovers a novel role for the endoplasmic reticulum in tethering mitochondria spe...
Abstract: Mitochondria are responsible for the essential role in the cell survival by regulating the...
In this issue of Developmental Cell, Elbaz-Alon et al. (2014) and Hönscher et al. (2014) describe a ...
Mitophagy, the selective degradation of mitochondria by autophagy, is implicated in the clearance of...
Mitophagy, the selective degradation of mitochondria by autophagy, is implicated in the clearance of...
SummaryDamaged and superfluous mitochondria are removed from the cell by selective autophagy, a proc...
AbstractMitochondria autophagy (mitophagy) is a process that selectively degrades mitochondria via a...
AbstractSelective degradation of mitochondria is a fundamental process that depends on formation of ...
AbstractMitochondria autophagy (mitophagy) is a process that selectively degrades mitochondria via a...
SummaryCellular life depends on continuous transport of lipids and small molecules between mitochond...
Mitochondria are critical for supplying energy to the cell, but during catabolism this organelle als...
Mitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regu...
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by...
The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an importa...
Eukaryotic cells rely on autophagy to degrade damaged or excess proteins and organelles. Autophagy c...
SummaryA new study uncovers a novel role for the endoplasmic reticulum in tethering mitochondria spe...
Abstract: Mitochondria are responsible for the essential role in the cell survival by regulating the...
In this issue of Developmental Cell, Elbaz-Alon et al. (2014) and Hönscher et al. (2014) describe a ...
Mitophagy, the selective degradation of mitochondria by autophagy, is implicated in the clearance of...
Mitophagy, the selective degradation of mitochondria by autophagy, is implicated in the clearance of...