The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae
- Abdel-Mottaleb, Yousra
- Clynen, Elke
- Jalali, Amir
- Bosmans, Frank
- Vatanpour, Hossein
- Schoofs, Liliane
- Tytgat, Jan
Publication date
November 2006
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractThe very first member of K+ channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically.OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as α-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K+ channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183±3nM but did not affect any of the other channels
Add to ORKG