The p16INK4a and p14ARF tumor suppressor genes (TSGs) are encoded within the CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the p53 and RB pathways. Inactivation of these genes by genetic and epigenetic changes has been described in some human cancers, but their importance in cutaneous squamous cell carcinoma (SCC) has not been established. Our detailed examination of 40 cutaneous SCC revealed loss of heterozygosity of 9p21 markers in 32.5% of cases. Mutational analysis confirmed five point mutations in four of 40 SCCs. These mutations changed the amino acid sequence of p16INK4a in four tumors and p14ARF in three tumors. Promoter methylation of p16INK4a and p14ARF was detected in 13 of 36 (36%) and 16 of 3...
The INK4a-ARF locus encodes two tumor suppressor proteins involved in cell-cycle regulation, p16INK4...
AbstractAberrant gene silencing is highly associated with altered cell cycle regulation during carci...
Cell cycle arrest at the G(1) checkpoint allows completion of critical macromolecular events prior t...
The p16INK4a and p14ARF tumor suppressor genes (TSGs) are encoded within the CDKN2A locus on chromos...
The p16INK4A tumor suppressor is often deleted, or otherwise inactivated, in malignant melanoma. To ...
Although the exact molecular mechanisms of Merkel cell carcinoma (MCC) tumorigenesis are unknown, th...
Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological...
The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a an...
The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently...
BackgroundThe tumor suppressors p14ARF (ARF) and p16INK4A (p16) are encoded by overlapping reading f...
Cutaneous squamous cell carcinoma (cSCC) is the second most com-mon human malignancy, oen arising fr...
The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to f...
Primary cutaneous B cell lymphomas represent a distinct group of lymphoproliferative disorders that ...
BACKGROUND: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivat...
Skin cancer is one of the most common forms of adult solid tumour. The incidence is increasing rapi...
The INK4a-ARF locus encodes two tumor suppressor proteins involved in cell-cycle regulation, p16INK4...
AbstractAberrant gene silencing is highly associated with altered cell cycle regulation during carci...
Cell cycle arrest at the G(1) checkpoint allows completion of critical macromolecular events prior t...
The p16INK4a and p14ARF tumor suppressor genes (TSGs) are encoded within the CDKN2A locus on chromos...
The p16INK4A tumor suppressor is often deleted, or otherwise inactivated, in malignant melanoma. To ...
Although the exact molecular mechanisms of Merkel cell carcinoma (MCC) tumorigenesis are unknown, th...
Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological...
The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a an...
The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently...
BackgroundThe tumor suppressors p14ARF (ARF) and p16INK4A (p16) are encoded by overlapping reading f...
Cutaneous squamous cell carcinoma (cSCC) is the second most com-mon human malignancy, oen arising fr...
The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to f...
Primary cutaneous B cell lymphomas represent a distinct group of lymphoproliferative disorders that ...
BACKGROUND: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivat...
Skin cancer is one of the most common forms of adult solid tumour. The incidence is increasing rapi...
The INK4a-ARF locus encodes two tumor suppressor proteins involved in cell-cycle regulation, p16INK4...
AbstractAberrant gene silencing is highly associated with altered cell cycle regulation during carci...
Cell cycle arrest at the G(1) checkpoint allows completion of critical macromolecular events prior t...