AbstractSeveral powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete potentially destructive autoantibodies. These mechanisms act in addition to the removal of self-reactive helper T cells
In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity,...
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segme...
ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant se...
B cells are essential for the development and pathogenesis of both systemic and organ-specific autoi...
Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the productio...
To prevent the formation of autoantibody mediated autoimmune diseases, autoreactive B cells are subj...
Our early concepts of the normal role of B cells in immunity focused on their ability to produce ant...
B cells are recognized as main actors in the autoimmune process. Autoreactive B cells can arise in t...
AbstractWe analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune ...
AbstractThe pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanis...
The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reac...
SummaryThe majority of early immature B cells express autoreactive B cell receptors (BCRs) that are,...
AbstractImmature B cells that encounter self-antigen are eliminated from the immune repertoire by ne...
B cell targeting therapies are effective in various autoimmune diseases, among others rheumatoid art...
The ability to distinguish self from nonself is crucial for proper immune system function, and disru...
In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity,...
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segme...
ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant se...
B cells are essential for the development and pathogenesis of both systemic and organ-specific autoi...
Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the productio...
To prevent the formation of autoantibody mediated autoimmune diseases, autoreactive B cells are subj...
Our early concepts of the normal role of B cells in immunity focused on their ability to produce ant...
B cells are recognized as main actors in the autoimmune process. Autoreactive B cells can arise in t...
AbstractWe analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune ...
AbstractThe pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanis...
The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reac...
SummaryThe majority of early immature B cells express autoreactive B cell receptors (BCRs) that are,...
AbstractImmature B cells that encounter self-antigen are eliminated from the immune repertoire by ne...
B cell targeting therapies are effective in various autoimmune diseases, among others rheumatoid art...
The ability to distinguish self from nonself is crucial for proper immune system function, and disru...
In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity,...
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segme...
ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant se...
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