Multidrug resistance–reversal effects of resin glycosides from Dichondra repens

AbstractInvestigation of hydrophobic extract of Dichondra repens (Convolvulaceae) led to the isolation of three new resin glycosides dichondrins A–C (1–3), and three known resin glycosides cus-1, cus-2, and cuse 3. All the isolated resin glycosides with an acyclic core were evaluated for their multidrug resistance reversal activities, and the combined use of these compounds at a concentration of 25μM increased the cytotoxicity of vincristine by 1.03–1.78-fold