Analgesic efficacy and safety of peri-operative pregabalin following radical cystectomy: A dose grading study

AbstractPurposeAdding novel drugs like pregabalin to analgesic regimens might reduce postoperative pain, total opioid consumption and side effects, this study compares multiple doses of pregabalin for postoperative analgesia following radical cystectomy.MethodsThis study is registered at www.clinicaltrials.gov at no.: NCT02724293. Sixty patients were randomized into 4 groups: Group I: control (placebo) group, Group II: received pregabalin 300mg 2h preoperatively, Group III: received pregabalin 300mg 2h preoperatively and 12h thereafter, Group IV: received pregabalin 600mg 2h preoperatively. Postoperative pain, time to first request of analgesia, and total morphine consumption were recorded.ResultsVAS was significantly reduced in groups II, III, IV in comparison with group I immediately postoperative, and after 2h (P<0.05). Sedation score was significantly higher in groups II, III, IV compared to group I immediately postoperative (P