AbstractSecreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled–Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome
Norrin is a secreted signaling molecule activating the Wnt/β-catenin pathway. Since Norrin protects ...
SummaryNorrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascu...
Norrin is a secreted signaling molecule activating the Wnt/beta-catenin pathway. Since Norrin protec...
AbstractThe Wnt signaling network is arguably one of the most complex molecular modules by which cel...
AbstractSecreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of ded...
AbstractIncomplete retinal vascularization occurs in both Norrie disease and familial exudative vitr...
Norrin is a secreted cystine-knot growth factor that plays critical roles in vascular development in...
The Wnt signaling pathway controls cell fate decisions during animal development and the self-renewa...
SummaryMutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or the l...
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between c...
SummaryMutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or the l...
Norrin is a retinal signaling molecule which is expressed in Muller glia and binds to Frizzled-4 to ...
Norrin is a retinal signaling molecule which is expressed in Muller glia and binds to Frizzled-4 to ...
AbstractRecent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal...
Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vasc...
Norrin is a secreted signaling molecule activating the Wnt/β-catenin pathway. Since Norrin protects ...
SummaryNorrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascu...
Norrin is a secreted signaling molecule activating the Wnt/beta-catenin pathway. Since Norrin protec...
AbstractThe Wnt signaling network is arguably one of the most complex molecular modules by which cel...
AbstractSecreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of ded...
AbstractIncomplete retinal vascularization occurs in both Norrie disease and familial exudative vitr...
Norrin is a secreted cystine-knot growth factor that plays critical roles in vascular development in...
The Wnt signaling pathway controls cell fate decisions during animal development and the self-renewa...
SummaryMutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or the l...
Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between c...
SummaryMutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or the l...
Norrin is a retinal signaling molecule which is expressed in Muller glia and binds to Frizzled-4 to ...
Norrin is a retinal signaling molecule which is expressed in Muller glia and binds to Frizzled-4 to ...
AbstractRecent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal...
Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vasc...
Norrin is a secreted signaling molecule activating the Wnt/β-catenin pathway. Since Norrin protects ...
SummaryNorrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascu...
Norrin is a secreted signaling molecule activating the Wnt/beta-catenin pathway. Since Norrin protec...
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