Maps for Changing Landscapes: Viewing Epigenomic Signatures through Differentiation

Enormous progress has been made in identifying chromatin “signatures” that define tissue-specific transcriptional networks. Three recent studies by Rada-Iglesias et al. (2012), Wamstad et al. (2012), and Paige et al. (2012) track such signatures during cellular differentiation, revealing a richer understanding of gene regulation and providing hints of new phenomena