Ultraviolet B (UVB) (290-320 nm) is capable of damaging the DNA molecule directly by generating predominantly pyrimidine dimers. UVA (320-400 nm) does not alter the DNA molecule directly. However, when it is absorbed by cellular photosensitizers, it can damage the DNA molecule indirectly, e.g., by mediation of singlet oxygen, generating predominantly 8-hydroxyguanine. These indirect effects have been implicated in the mutagenic, genotoxic, and carciogenic effects of UVA. To study the processing of directly and indirectly UV-induced DNA damage in intact, DNA-repair-proficient and -deficient human cells, we used the replicating plasmid pRSV cat, either irradiated with up to 10 kJ/m2 UVB or treated with the photosensitizer methylene blue plus ...
Cells from most patients with xeroderma pigmentosum (XP) can be shown to be defective in repairing u...
To understand the relationship between DNA repair, apoptosis, transcription, and cancer-proneness, w...
Although it is known that sunlight is carcinogenic, few molecular data are available concerning the ...
An important feature of living cells is their capacity to maintain the integrity of their hereditary...
textabstractAn important feature of living cells is their capacity to maintain the integrity of thei...
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the m...
Cells that have been irradiated with ultraviolet light (UV) suffer damage to their DNA, primarily in...
The subjects are three patients with distinct symptoms of xeroderma pigmentosum (XP) in which the cu...
Patients with the variant form of xeroderma pigmentosum (XP) have clinical XP including a high frequ...
Ultraviolet B irradiation has serious consequences for cellular immunity and can suppress the reject...
Cells defective in one or more aspects of repair are killed and often mutagenized more readily than ...
It is generally presumed that xeroderma pigmentosum (XP) patients are extremely sensitive to develop...
Sunlight and some environmental chemical agents produce lesions in the DNA of human skin cells that ...
Copyright @ 2010 Gopalakrishnan et al; licensee BioMed Central Ltd.Background The Nucleotide Excisio...
This study was performed to elucidate whether xeroderma pigmentosum complementation group A (XPA) ca...
Cells from most patients with xeroderma pigmentosum (XP) can be shown to be defective in repairing u...
To understand the relationship between DNA repair, apoptosis, transcription, and cancer-proneness, w...
Although it is known that sunlight is carcinogenic, few molecular data are available concerning the ...
An important feature of living cells is their capacity to maintain the integrity of their hereditary...
textabstractAn important feature of living cells is their capacity to maintain the integrity of thei...
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the m...
Cells that have been irradiated with ultraviolet light (UV) suffer damage to their DNA, primarily in...
The subjects are three patients with distinct symptoms of xeroderma pigmentosum (XP) in which the cu...
Patients with the variant form of xeroderma pigmentosum (XP) have clinical XP including a high frequ...
Ultraviolet B irradiation has serious consequences for cellular immunity and can suppress the reject...
Cells defective in one or more aspects of repair are killed and often mutagenized more readily than ...
It is generally presumed that xeroderma pigmentosum (XP) patients are extremely sensitive to develop...
Sunlight and some environmental chemical agents produce lesions in the DNA of human skin cells that ...
Copyright @ 2010 Gopalakrishnan et al; licensee BioMed Central Ltd.Background The Nucleotide Excisio...
This study was performed to elucidate whether xeroderma pigmentosum complementation group A (XPA) ca...
Cells from most patients with xeroderma pigmentosum (XP) can be shown to be defective in repairing u...
To understand the relationship between DNA repair, apoptosis, transcription, and cancer-proneness, w...
Although it is known that sunlight is carcinogenic, few molecular data are available concerning the ...