A paper published in the September 8 issue of Cell [1] describes a generally applicable approach for chemical control of protein stability, with potential for broad use in chemical genetics
To understand biological processes, biologists typically study how perturbations of protein function...
More than 300,000 Protein–Protein Interactions (PPIs) can be found in human cells. This number is si...
In this issue of Chemistry & Biology, Duckmanton et al. [1] have rigorously studied myotube fragment...
Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banas...
The challenge of studying complex protein networks in whole animals has driven the development of ne...
SummaryThe ability to make specific perturbations to biological molecules in a cell or organism is a...
SummaryRapid and reversible methods for perturbing the function of specific proteins are desirable t...
Biological small-molecule-dependent switches sense external chemical signals and transduce them into...
To understand biological processes, biologists typically study how perturbations of protein function...
A common strategy to understand a biological system is to selectively perturb it and observe its res...
Protein stability is often a limiting factor in the development of commercial proteins and biopharma...
Here we discuss, how by applying chemical concepts to biological problems, methods have been develop...
<p>Driven by the development of new technologies and an ever expanding knowledge base of molecular a...
Chemical genetics is the study of biological systems using small molecule (‘chemical’) intervention,...
SummaryLoss- and gain-of-function transgenic models are powerful tools for understanding gene functi...
To understand biological processes, biologists typically study how perturbations of protein function...
More than 300,000 Protein–Protein Interactions (PPIs) can be found in human cells. This number is si...
In this issue of Chemistry & Biology, Duckmanton et al. [1] have rigorously studied myotube fragment...
Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banas...
The challenge of studying complex protein networks in whole animals has driven the development of ne...
SummaryThe ability to make specific perturbations to biological molecules in a cell or organism is a...
SummaryRapid and reversible methods for perturbing the function of specific proteins are desirable t...
Biological small-molecule-dependent switches sense external chemical signals and transduce them into...
To understand biological processes, biologists typically study how perturbations of protein function...
A common strategy to understand a biological system is to selectively perturb it and observe its res...
Protein stability is often a limiting factor in the development of commercial proteins and biopharma...
Here we discuss, how by applying chemical concepts to biological problems, methods have been develop...
<p>Driven by the development of new technologies and an ever expanding knowledge base of molecular a...
Chemical genetics is the study of biological systems using small molecule (‘chemical’) intervention,...
SummaryLoss- and gain-of-function transgenic models are powerful tools for understanding gene functi...
To understand biological processes, biologists typically study how perturbations of protein function...
More than 300,000 Protein–Protein Interactions (PPIs) can be found in human cells. This number is si...
In this issue of Chemistry & Biology, Duckmanton et al. [1] have rigorously studied myotube fragment...
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