SummaryMany inherited cancer-prone conditions show an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation, indicative of defects in the processing of DNA damage. We earlier found that 40% of patients with breast cancer and 5%–10% of controls showed evidence of enhanced chromosomal radiosensitivity and that this sensitivity was not age related. We suggested that this could be a marker of cancer-predisposing genes of low penetrance. To further test this hypothesis, we have studied the heritability of radiosensitivity in families of patients with breast cancer. Of 37 first-degree relatives of 16 sensitive patients, 23 (62%) were themselves sensitive, compared with 1 (7%) of 15 first-degree relative...
Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic back-ground. H...
In vitro chromosomal radiosensitivity has been investigated in patients with inherited cancer prone ...
The prediction of sensitivities of both tumor and the surrounding healthy tissue is important for ef...
It is increasingly recognised that individual risk of cancer may be related to genetically determin...
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutati...
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 ...
The clinical radiosensitivity of normal tissue is likely to be a complex trait that isdependent on t...
A substantial proportion of women with breast cancer exhibit an abnormally high radiosensitivity as ...
<div><p>High dose ionizing radiation (IR) is a well-known risk factor for breast cancer but the heal...
Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic background. Ho...
High dose ionizing radiation (IR) is a well-known risk factor for breast cancer but the health effec...
Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent ...
Breast cancer is one of the most common types of neoplasia in females in Western industrialised coun...
Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic back-ground. H...
In vitro chromosomal radiosensitivity has been investigated in patients with inherited cancer prone ...
The prediction of sensitivities of both tumor and the surrounding healthy tissue is important for ef...
It is increasingly recognised that individual risk of cancer may be related to genetically determin...
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutati...
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 ...
The clinical radiosensitivity of normal tissue is likely to be a complex trait that isdependent on t...
A substantial proportion of women with breast cancer exhibit an abnormally high radiosensitivity as ...
<div><p>High dose ionizing radiation (IR) is a well-known risk factor for breast cancer but the heal...
Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic background. Ho...
High dose ionizing radiation (IR) is a well-known risk factor for breast cancer but the health effec...
Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent ...
Breast cancer is one of the most common types of neoplasia in females in Western industrialised coun...
Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic back-ground. H...
In vitro chromosomal radiosensitivity has been investigated in patients with inherited cancer prone ...
The prediction of sensitivities of both tumor and the surrounding healthy tissue is important for ef...