AbstractPancreatic cancer is characterised by a highly malignant phenotype with a marked resistance to conventional therapies and to apoptotic activators. Here, we demonstrate that sodium butyrate (NaBt), an inhibitor of histone deacetylases, sensitises human pancreatic cancer cell lines to both mitochondria- and Fas-mediated apoptosis. The analysis of anti-apoptotic and pro-apoptotic members of the Bcl-2 family in untreated pancreatic cancer cell lines shows a generalised low expression of Bcl-2 and a strong expression of Bcl-xL. NaBt treatment results in a marked down-regulation of Bcl-xL expression, mitochondrial membrane depolarization, cytochrome c release from mitochondria, activation of caspase-9 and -3 and apoptosis induction. Furth...
Introduction: The gastrointestinal malignancy, gastric cancer (GC), has a high incidence worldwide. ...
AbstractWe report that sodium butyrate, a natural product of fiber degradation by colonic bacteria, ...
SummaryShort-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetyl...
Pancreatic cancer is characterised by a highly malignant phenotype with a marked resistance to conve...
AbstractPancreatic cancer is characterised by a highly malignant phenotype with a marked resistance ...
Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation ...
AbstractBackground: Several tumor-suppressor genes, such as 53-kDa protein (p53), are inactivated in...
Abstract Background Sodium butyrate (NaBu) is a short-chain fatty acid which serves as a histon deac...
Sodium butyrate (butyrate) is a potent growth inhibitor and differentiating agent for many cell type...
Butyrate can promote programmed cell death in a number of tumour cells in vitro. This paper provides...
This study deals with the apoptotic effect exerted on human retinoblastoma Y79 cells by both sodium ...
BACKGROUND: Sodium butyrate, a histone deacetylase inhibitor, has emerged as a promising anticancer ...
Sodium butyrate, a histone deacetylase inhibitor, has emerged as a promising anticancer drug for mul...
Background: Sodium butyrate, a histone deacetylase inhibitor, has emerged as a promising anticancer ...
Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cance...
Introduction: The gastrointestinal malignancy, gastric cancer (GC), has a high incidence worldwide. ...
AbstractWe report that sodium butyrate, a natural product of fiber degradation by colonic bacteria, ...
SummaryShort-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetyl...
Pancreatic cancer is characterised by a highly malignant phenotype with a marked resistance to conve...
AbstractPancreatic cancer is characterised by a highly malignant phenotype with a marked resistance ...
Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation ...
AbstractBackground: Several tumor-suppressor genes, such as 53-kDa protein (p53), are inactivated in...
Abstract Background Sodium butyrate (NaBu) is a short-chain fatty acid which serves as a histon deac...
Sodium butyrate (butyrate) is a potent growth inhibitor and differentiating agent for many cell type...
Butyrate can promote programmed cell death in a number of tumour cells in vitro. This paper provides...
This study deals with the apoptotic effect exerted on human retinoblastoma Y79 cells by both sodium ...
BACKGROUND: Sodium butyrate, a histone deacetylase inhibitor, has emerged as a promising anticancer ...
Sodium butyrate, a histone deacetylase inhibitor, has emerged as a promising anticancer drug for mul...
Background: Sodium butyrate, a histone deacetylase inhibitor, has emerged as a promising anticancer ...
Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cance...
Introduction: The gastrointestinal malignancy, gastric cancer (GC), has a high incidence worldwide. ...
AbstractWe report that sodium butyrate, a natural product of fiber degradation by colonic bacteria, ...
SummaryShort-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetyl...