AbstractA q × n array with entries from 0, 1,...,q − 1 is said to form a difference matrix if the vector difference (modulo q) of each pair of columns consists of a permutation of [0, 1,... q − 1]; this definition is inverted from the more standard one to be found, e.g., in Colbourn and de Launey (1996). The following idea generalizes this notion: Given an appropriate δ (-[−1, 1]t, a λq × n array will be said to form a (t, q, λ, Δ) sign-balanced matrix if for each choice C1, C2,..., Ct of t columns and for each choice ɛ = (ɛ1,...,ɛt) ∈ Δ of signs, the linear combination ∑j=1tεjCj contains (mod q) each entry of [0, 1,...,q − 1] exactly λ times. We consider the following extremal problem in this paper: How large does the number k = k(n, t, q,...