Spectrophotometric determination of procainamide hydrochloride using sodium periodate

AbstractA simple spectrophotometric method has been described for the determination of procainamide hydrochloride. The method is based on the oxidation of procainamide hydrochloride by sodium periodate in the presence of sulfuric acid and measurement of the absorbance of the violet color formed at 531nm. Parameters affecting the reaction were studied and conditions were optimized. Linear calibration graph was obtained from 50 to 700μgml−1 of procainamide hydrochloride and the limit of detection was 25μgml−1. The method was successfully applied for the determination of procainamide hydrochloride in pharmaceutical preparation