In this issue of Cancer Cell, Xiao et al. report that PLC-β3 mutant mice develop myeloprolfierative neoplasms and show that tumor suppressor activity does not require PLC-β3 catalytic activity. Instead, PLC-β3 forms a complex with SHP-1 and Stat5 that facilitates Stat5 dephosphorylation. A similar mechanism may be operative in some human leukemias
Mutations that deregulate proliferation and survival pathways have emerged as a common molecular the...
AbstractPhospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell prolife...
SummaryWe show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT,...
In this issue of Cancer Cell, Xiao et al. report that PLC-β3 mutant mice develop myeloprolfierative ...
SummaryGiven its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, pho...
Given its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, phospholip...
Phospholipase C β1 (PLCβ1) is known to play an important role in cell proliferation. Previous studie...
SummaryThe SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytok...
Cancer stem cells (CSCs) are a class of cancer cells characterized by self-renewal, differentiation ...
Phospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple cellula...
Previous studies have established constitutive activation of Stat3 protein as one of the molecular c...
AbstractPhospholipase activity is elevated in dividing cells. In response to growth factor stimulati...
AbstractWe have examined the effect of expression of the protein tyrosine phosphatase Shp2 on transf...
Summary“Oncogene addiction” describes an unexplained dependency of cancer cells on a particular cell...
BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription ...
Mutations that deregulate proliferation and survival pathways have emerged as a common molecular the...
AbstractPhospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell prolife...
SummaryWe show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT,...
In this issue of Cancer Cell, Xiao et al. report that PLC-β3 mutant mice develop myeloprolfierative ...
SummaryGiven its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, pho...
Given its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, phospholip...
Phospholipase C β1 (PLCβ1) is known to play an important role in cell proliferation. Previous studie...
SummaryThe SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytok...
Cancer stem cells (CSCs) are a class of cancer cells characterized by self-renewal, differentiation ...
Phospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple cellula...
Previous studies have established constitutive activation of Stat3 protein as one of the molecular c...
AbstractPhospholipase activity is elevated in dividing cells. In response to growth factor stimulati...
AbstractWe have examined the effect of expression of the protein tyrosine phosphatase Shp2 on transf...
Summary“Oncogene addiction” describes an unexplained dependency of cancer cells on a particular cell...
BACKGROUND & AIMS: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription ...
Mutations that deregulate proliferation and survival pathways have emerged as a common molecular the...
AbstractPhospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell prolife...
SummaryWe show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT,...
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