AbstractThe transposon Tn5 carries a gene, ble, which confers resistance to bleomycin (Bm) and gives a survival advantage to its host cell. We found that the ble gene product, designated BLMT, is a binding protein with a strong affinity for Bm. BLMT quenched both the antibacterial and DNA-cleaving activities of Bm, when incubated with the antibiotic. An electron spin resonance spin-trapping analysis showed that BLMT inhibits the generation of Bm-induced hydroxyl radical, by trapping Bm but not the hydroxyl radical. Western blot analysis using an anti-BLMT monoclonal antibody revealed that BLMT is immunologically distinct from Bm-binding proteins from Streptomyces verticillus, Staphylococcus aureus and Streptoalloteichus hindustanus. Escheri...
To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance...
Mitomycin C (MMC), a DNA-damaging agent, is a potent inducer of the bacterial SOS response; surprisi...
Copyright © 2016, American Society for Microbiology. All Rights Reserved. blaNDM genes confer carbap...
AbstractThe protein coded by a bleomycin-resistance gene (ble) cloned from producing actinomycetes w...
The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading ...
AbstractThe bleomycin-binding proteins designated BLMA and BLMS, which confer resistance to bleomyci...
The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading w...
AbstractA gene, blmA, from bleomycin (Bm)-producing Streptomyces verticillus, encodes a Bm-binding p...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
Plant cells are sensitive to the antibiotic bleomycin, a DNA damaging glycopeptide. A bleomycin resi...
The bleomycins (BLMs), tallysomycins (TLMs), phleomycin, and zorbamycin (ZBM) are members of the BLM...
<div><p>Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due ...
beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam...
To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance...
Mitomycin C (MMC), a DNA-damaging agent, is a potent inducer of the bacterial SOS response; surprisi...
Copyright © 2016, American Society for Microbiology. All Rights Reserved. blaNDM genes confer carbap...
AbstractThe protein coded by a bleomycin-resistance gene (ble) cloned from producing actinomycetes w...
The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading ...
AbstractThe bleomycin-binding proteins designated BLMA and BLMS, which confer resistance to bleomyci...
The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading w...
AbstractA gene, blmA, from bleomycin (Bm)-producing Streptomyces verticillus, encodes a Bm-binding p...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
Plant cells are sensitive to the antibiotic bleomycin, a DNA damaging glycopeptide. A bleomycin resi...
The bleomycins (BLMs), tallysomycins (TLMs), phleomycin, and zorbamycin (ZBM) are members of the BLM...
<div><p>Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due ...
beta-Lactamase and penicillin-binding protein PBP2' mediate staphylococcal resistance to beta-lactam...
To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance...
Mitomycin C (MMC), a DNA-damaging agent, is a potent inducer of the bacterial SOS response; surprisi...
Copyright © 2016, American Society for Microbiology. All Rights Reserved. blaNDM genes confer carbap...