AbstractTolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo
Opioids are some of the most efficacious analgesics used in humans. Prolonged administration of opio...
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known fo...
AbstractOpiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the μ ...
AbstractTolerance, one of several behavioral adaptations to prolonged opioid treatment, has long bee...
International audienceTolerance, one of several behavioral adaptations to prolonged opioid treatment...
AbstractControl of trafficking of g protein-linked receptors is thought to be an important regulator...
ABSTRACT The cellular basis of tolerance to, and dependence upon, many types of drugs, including opi...
Internalisation of the mu opioid receptor from the surface of cells is generally achieved by recepto...
Opioids remain among the most effective pain-relieving therapeutics. However, their long-term use is...
AbstractThe utility of morphine for the treatment of chronic pain is hindered by the development of ...
Agonists acting on µ-opioid receptors (MOR) are very effective analgesics but cause tolerance during...
Opiate drugs produce analgesia by activation of opioid receptors (MOP-r), a class of G protein-coup...
Development of antinociceptive tolerance in the clinic after repeated administration of morphine lim...
University of Minnesota Ph.D. dissertation. December 2009. Major: Pharmacology. Advisor: Dr. Ping-Ye...
-Opioid receptor desensitization is considered an initial step in the development of tolerance. Curi...
Opioids are some of the most efficacious analgesics used in humans. Prolonged administration of opio...
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known fo...
AbstractOpiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the μ ...
AbstractTolerance, one of several behavioral adaptations to prolonged opioid treatment, has long bee...
International audienceTolerance, one of several behavioral adaptations to prolonged opioid treatment...
AbstractControl of trafficking of g protein-linked receptors is thought to be an important regulator...
ABSTRACT The cellular basis of tolerance to, and dependence upon, many types of drugs, including opi...
Internalisation of the mu opioid receptor from the surface of cells is generally achieved by recepto...
Opioids remain among the most effective pain-relieving therapeutics. However, their long-term use is...
AbstractThe utility of morphine for the treatment of chronic pain is hindered by the development of ...
Agonists acting on µ-opioid receptors (MOR) are very effective analgesics but cause tolerance during...
Opiate drugs produce analgesia by activation of opioid receptors (MOP-r), a class of G protein-coup...
Development of antinociceptive tolerance in the clinic after repeated administration of morphine lim...
University of Minnesota Ph.D. dissertation. December 2009. Major: Pharmacology. Advisor: Dr. Ping-Ye...
-Opioid receptor desensitization is considered an initial step in the development of tolerance. Curi...
Opioids are some of the most efficacious analgesics used in humans. Prolonged administration of opio...
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known fo...
AbstractOpiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the μ ...
DOI
Add to ORKG