SummarySpatiotemporal control of microtubule depolymerization during cell division underlies the construction and dynamics of mitotic and meiotic spindles. Owing to their potent ability to disassemble microtubules, Kinesin-13s constitute an important class of microtubule destabilizing factors. Unfertilized Xenopus eggs, similar to other metazoan cells, contain the prototypical Kinesin-13 MCAK as well as a second family member, XKIF2. Here, we compare the roles of MCAK and XKIF2 during spindle assembly in Xenopus extracts. We find that although MCAK and XKIF2 have similar localization and biochemical properties, XKIF2 is not required for spindle assembly and, further, cannot substitute for MCAK. Altering dosage of the two kinesins demonstrat...
SummaryKinesins in the mitotic spindle play major roles in determining spindle shape, size, and bipo...
AbstractXenopus kinesin catastrophe modulator-1 (XKCM1) is a Kin I kinesin family member that uses t...
Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubul...
SummarySpatiotemporal control of microtubule depolymerization during cell division underlies the con...
Metaphase spindles assemble to a steady state in length by mechanisms that involve microtubule dynam...
SummaryDuring cell division, correct positioning of chromosomes in mitotic and meiotic spindles depe...
AbstractWe isolated a cDNA clone encoding a kinesin-related protein, which we named XKCM1. Antibodie...
AbstractBackground: Sister kinetochores must bind microtubules in a bipolar fashion to equally segre...
Author Posting. © American Society for Cell Biology, 2005. This article is posted here by permissio...
AbstractMitosis requires precise control of microtubule dynamics. The KinI kinesin MCAK, a microtubu...
AbstractIn higher eukaryotes, microtubules (MT) in both halves of the mitotic spindle translocate co...
AbstractBackground: In eukaryotes, assembly of the mitotic spindle requires the interaction of chrom...
AbstractDuring cell division, the proper formation of a bipolar spindle and its function to segregat...
The spindle is a self-assembled, bipolar structure responsible for segregating chromosomes to daught...
AbstractWe describe a novel Xenopus plus end–directed kinesin-like protein (KLP), Xklp2, localized o...
SummaryKinesins in the mitotic spindle play major roles in determining spindle shape, size, and bipo...
AbstractXenopus kinesin catastrophe modulator-1 (XKCM1) is a Kin I kinesin family member that uses t...
Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubul...
SummarySpatiotemporal control of microtubule depolymerization during cell division underlies the con...
Metaphase spindles assemble to a steady state in length by mechanisms that involve microtubule dynam...
SummaryDuring cell division, correct positioning of chromosomes in mitotic and meiotic spindles depe...
AbstractWe isolated a cDNA clone encoding a kinesin-related protein, which we named XKCM1. Antibodie...
AbstractBackground: Sister kinetochores must bind microtubules in a bipolar fashion to equally segre...
Author Posting. © American Society for Cell Biology, 2005. This article is posted here by permissio...
AbstractMitosis requires precise control of microtubule dynamics. The KinI kinesin MCAK, a microtubu...
AbstractIn higher eukaryotes, microtubules (MT) in both halves of the mitotic spindle translocate co...
AbstractBackground: In eukaryotes, assembly of the mitotic spindle requires the interaction of chrom...
AbstractDuring cell division, the proper formation of a bipolar spindle and its function to segregat...
The spindle is a self-assembled, bipolar structure responsible for segregating chromosomes to daught...
AbstractWe describe a novel Xenopus plus end–directed kinesin-like protein (KLP), Xklp2, localized o...
SummaryKinesins in the mitotic spindle play major roles in determining spindle shape, size, and bipo...
AbstractXenopus kinesin catastrophe modulator-1 (XKCM1) is a Kin I kinesin family member that uses t...
Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubul...