In a recent paper in Nature, Barber et al. (2005) show that the immunoreceptor PD-1 is upregulated by “exhausted” T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load
Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cell...
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor...
Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with re...
In a recent paper in Nature, Barber et al. (2005) show that the immunoreceptor PD-1 is upregulated b...
Immune responses to persistent viral infections often fail because of intense regulation of antigen-...
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to dis...
Programmed Death-1 (PD-1) is a CD-28 family inhibitory immune receptor that is located on Tc cells, ...
The PD-1/PD-L pathway plays a major role in regulating T-cell exhaustion during chronic viral infect...
Cytotoxic CD8+ T lymphocytes (CTL) efficiently control acute virus infections but can become exhaust...
SummaryFunctionally exhausted T cells have high expression of the PD-1 inhibitory receptor, and ther...
PD-1 and its ligands, PD-L1 and PD-L2, constitute a critical immunoregulatory pathway for modulating...
PD-1 and its ligands, PD-L1 and PD-L2, constitute a critical immunoregulatory pathway for modulating...
SummaryChronic viral infections often result in T cell exhaustion. To determine the molecular signat...
Exhausted T cells are associated with ineffective and dysfunctional immune responses that often occu...
2 The PD-1:PD-L pathway plays a major role in regulating T cell exhaustion during chronic viral infe...
Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cell...
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor...
Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with re...
In a recent paper in Nature, Barber et al. (2005) show that the immunoreceptor PD-1 is upregulated b...
Immune responses to persistent viral infections often fail because of intense regulation of antigen-...
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to dis...
Programmed Death-1 (PD-1) is a CD-28 family inhibitory immune receptor that is located on Tc cells, ...
The PD-1/PD-L pathway plays a major role in regulating T-cell exhaustion during chronic viral infect...
Cytotoxic CD8+ T lymphocytes (CTL) efficiently control acute virus infections but can become exhaust...
SummaryFunctionally exhausted T cells have high expression of the PD-1 inhibitory receptor, and ther...
PD-1 and its ligands, PD-L1 and PD-L2, constitute a critical immunoregulatory pathway for modulating...
PD-1 and its ligands, PD-L1 and PD-L2, constitute a critical immunoregulatory pathway for modulating...
SummaryChronic viral infections often result in T cell exhaustion. To determine the molecular signat...
Exhausted T cells are associated with ineffective and dysfunctional immune responses that often occu...
2 The PD-1:PD-L pathway plays a major role in regulating T cell exhaustion during chronic viral infe...
Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cell...
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor...
Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with re...
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