Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD+ levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD+ depletion by the DNA repair protein PARP
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated ...
The ketogenic diet’s (KD) anti-seizure effects have long been documented. Recently, its therapeutic ...
Nicotinamide adenine dinucleotide (NAD[superscript +]) is a classical coenzyme mediating many redox ...
Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of C...
SummaryCockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodeg...
SummaryCockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodeg...
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegenerati...
SummaryMitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mit...
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for s...
Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide a...
SummaryNAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate ...
Due to external and internal exposures, cells accumulate enormous amounts of damage to DNA every day...
Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in p...
As we age and across various types of disease, levels of the molecule NAD+ (nicoti- namide adenine d...
SummaryEver since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitoch...
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated ...
The ketogenic diet’s (KD) anti-seizure effects have long been documented. Recently, its therapeutic ...
Nicotinamide adenine dinucleotide (NAD[superscript +]) is a classical coenzyme mediating many redox ...
Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of C...
SummaryCockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodeg...
SummaryCockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodeg...
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegenerati...
SummaryMitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mit...
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for s...
Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide a...
SummaryNAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate ...
Due to external and internal exposures, cells accumulate enormous amounts of damage to DNA every day...
Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in p...
As we age and across various types of disease, levels of the molecule NAD+ (nicoti- namide adenine d...
SummaryEver since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitoch...
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated ...
The ketogenic diet’s (KD) anti-seizure effects have long been documented. Recently, its therapeutic ...
Nicotinamide adenine dinucleotide (NAD[superscript +]) is a classical coenzyme mediating many redox ...
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