High expression of telomerase in embryonic stem cells (ESCs) is important for their maintenance, but whether telomere length affects lineage commitment is unknown. In this issue of Cell Stem Cell, Pucci et al. (2013) reveal that ESCs with short telomeres exhibit unstable differentiation by inducing altered DNA methylation
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Telomeres are the terminal structures at the ends of linear chromosomes that represent a solution to...
AbstractStem cells regenerate our bodies. In a similar manner to match ignition, stem cell “ignition...
SummaryAutosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telome...
SummaryFunctional telomeres are critical for stem cell proliferation; however, whether they are equa...
SummaryTelomere shortening is associated with organismal aging. iPS cells have been recently derived...
Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, an...
Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs) and induced p...
Telomeres cap the ends of eukaryotic chromosomes, masking the end from DNA repair processes and prev...
Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell...
Telomeres are the repetitive sequences at the ends of linear chromosomes. Thekey functions of telome...
AbstractLoss of telomere function can induce cell cycle arrest and apoptosis. To investigate the pro...
In this issue of Cell Stem Cell, Marion et al. (2009) report that efficient production of iPSCs requ...
The epigenetic nature of telomeres is still controversial and different human cell lines might show ...
Telomeres are specialized structures that cap the ends of eukaryotic chromosomes and, together with ...
Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core c...
Telomeres are the terminal structures at the ends of linear chromosomes that represent a solution to...
AbstractStem cells regenerate our bodies. In a similar manner to match ignition, stem cell “ignition...
SummaryAutosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telome...
SummaryFunctional telomeres are critical for stem cell proliferation; however, whether they are equa...
SummaryTelomere shortening is associated with organismal aging. iPS cells have been recently derived...
Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, an...
Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs) and induced p...
Telomeres cap the ends of eukaryotic chromosomes, masking the end from DNA repair processes and prev...
Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell...
Telomeres are the repetitive sequences at the ends of linear chromosomes. Thekey functions of telome...
AbstractLoss of telomere function can induce cell cycle arrest and apoptosis. To investigate the pro...
In this issue of Cell Stem Cell, Marion et al. (2009) report that efficient production of iPSCs requ...
The epigenetic nature of telomeres is still controversial and different human cell lines might show ...
Telomeres are specialized structures that cap the ends of eukaryotic chromosomes and, together with ...
Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core c...
Telomeres are the terminal structures at the ends of linear chromosomes that represent a solution to...
AbstractStem cells regenerate our bodies. In a similar manner to match ignition, stem cell “ignition...
SummaryAutosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telome...
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