AbstractObjectives: Cardiopulmonary bypass is associated with an inflammatory response that is associated with a neutrophil-mediated microvascular barrier injury. We studied the effects of blocking neutrophil-endothelial tethering on microvascular permeability and edema formation during cardiopulmonary bypass. Using a selectin antagonist that prevents interactions with their ligands, we hypothesized that there would be less neutrophil infiltration into the tissue and a reduction in microvascular permeability and edema formation. Methods: A canine mesenteric lymphatic fistula was created to measure Starling forces and to determine microvascular permeability. Normothermic, atrial-femoral cardiopulmonary bypass was initiated (70-90 mL · kg–1 ·...
Complications occur in up to 70% of patients undergoing surgery and may lead to further morbidity or...
AbstractBackground: Aprotinin is a serine protease inhibitor used extensively in cardiac operations ...
AbstractBackground: Activation of neutrophil adhesion molecules and subsequent neutrophil adhesion t...
AbstractObjectives: Cardiopulmonary bypass is associated with an inflammatory response that is assoc...
AbstractObjectives: P-selectin participates in the development of inflammatory disorders. Cardiopulm...
AbstractBackground: The initial step in the inflammatory process, which can be initiated by cardiopu...
AbstractOBJECTIVESThis study was designed to determine whether antibody neutralization of the adhesi...
Background Cardiopulmonary bypass during cardiac surgery leads to impaired microcirculatory perfusio...
Abstract—The adhesion of neutrophils to damaged arterial surfaces is increased in the presence of pl...
Objective: Cardiac surgery with cardiopulmonary bypass induces ischemia to the heart, hypoxemia to v...
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopu...
AbstractObjectiveCardiopulmonary bypass triggers a systemic inflammatory response that alters pulmon...
Objective: Cardiac surgery with cardiopulmonary bypass induces ischemia to the heart, hypoxemia to v...
P-selectin, a member of the selectin family of adhesion molecules, is believed to play a significant...
AbstractOBJECTIVESThe role of P-selectin in the process of restenosis was evaluated using a recombin...
Complications occur in up to 70% of patients undergoing surgery and may lead to further morbidity or...
AbstractBackground: Aprotinin is a serine protease inhibitor used extensively in cardiac operations ...
AbstractBackground: Activation of neutrophil adhesion molecules and subsequent neutrophil adhesion t...
AbstractObjectives: Cardiopulmonary bypass is associated with an inflammatory response that is assoc...
AbstractObjectives: P-selectin participates in the development of inflammatory disorders. Cardiopulm...
AbstractBackground: The initial step in the inflammatory process, which can be initiated by cardiopu...
AbstractOBJECTIVESThis study was designed to determine whether antibody neutralization of the adhesi...
Background Cardiopulmonary bypass during cardiac surgery leads to impaired microcirculatory perfusio...
Abstract—The adhesion of neutrophils to damaged arterial surfaces is increased in the presence of pl...
Objective: Cardiac surgery with cardiopulmonary bypass induces ischemia to the heart, hypoxemia to v...
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopu...
AbstractObjectiveCardiopulmonary bypass triggers a systemic inflammatory response that alters pulmon...
Objective: Cardiac surgery with cardiopulmonary bypass induces ischemia to the heart, hypoxemia to v...
P-selectin, a member of the selectin family of adhesion molecules, is believed to play a significant...
AbstractOBJECTIVESThe role of P-selectin in the process of restenosis was evaluated using a recombin...
Complications occur in up to 70% of patients undergoing surgery and may lead to further morbidity or...
AbstractBackground: Aprotinin is a serine protease inhibitor used extensively in cardiac operations ...
AbstractBackground: Activation of neutrophil adhesion molecules and subsequent neutrophil adhesion t...