AbstractEstrogen withdrawal, a characteristic of female aging, is associated with age-related intervertebral disc (IVD) degeneration. The function of estrogen is mediated by two classic nuclear receptors, estrogen receptor (ER)-α and -β, and a membrane bound G-protein-coupled receptor 30 (GPR30). To date, the expression and function of GPR30 in human spine is poorly understood. This study aimed to evaluate GPR30 expression in IVD, and its role in estrogen-related regulation of proliferation and apoptosis of disc nucleus pulposus (NP) cells. GPR30 expression was examined in 30 human adult NP and 9 fetal IVD. Results showed that GPR30 was expressed in NP cells at both mRNA and protein levels. In human fetal IVD, GPR30 protein was expressed in...
AbstractEstrogen receptor-related receptor-α (ERRα) is an orphan member of the nuclear receptor supe...
Estrogen plays several important physiological and pathological functions in not only reproductive s...
Sex steroids, such as Estrogen, play important roles in physiological and pathological processes, in...
Abstract Background Recent evidence suggests that estrogens exert effects in different tissues throu...
Background/Aims: Matrix homeostasis within the disc nucleus pulposus (NP) tissue is important for di...
SummaryObjectiveThe role of postmenopause on the pathogenesis of cartilage degeneration has been an ...
Windahl SH, Andersson N, Chagin AS, Martensson UEA, Carlsten H, Olde B, Swanson C, Moverare-Skrtic S...
In vitro studies suggest that the membrane G protein-coupled receptor GPR30 is a functional estrogen...
Estradiol (E2) has many important actions in the tissues of the oral cavity. Disruption of E2 metabo...
Epidemiological studies have indicated that Alzheimer’s disease (AD) is more common in females and t...
Estrogens are important endocrine regulators of skeletal growth and maintenance in both females and ...
The incidence of cardiovascular diseases was significantly increased in postmenopausal women. The pr...
Abstract Background The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection again...
Much is known about estrogen action in experimental animal models and in human physiology. This arti...
Although 17\u3b2-estradiol (E2) anti-inflammatory activity has been well described, very little is k...
AbstractEstrogen receptor-related receptor-α (ERRα) is an orphan member of the nuclear receptor supe...
Estrogen plays several important physiological and pathological functions in not only reproductive s...
Sex steroids, such as Estrogen, play important roles in physiological and pathological processes, in...
Abstract Background Recent evidence suggests that estrogens exert effects in different tissues throu...
Background/Aims: Matrix homeostasis within the disc nucleus pulposus (NP) tissue is important for di...
SummaryObjectiveThe role of postmenopause on the pathogenesis of cartilage degeneration has been an ...
Windahl SH, Andersson N, Chagin AS, Martensson UEA, Carlsten H, Olde B, Swanson C, Moverare-Skrtic S...
In vitro studies suggest that the membrane G protein-coupled receptor GPR30 is a functional estrogen...
Estradiol (E2) has many important actions in the tissues of the oral cavity. Disruption of E2 metabo...
Epidemiological studies have indicated that Alzheimer’s disease (AD) is more common in females and t...
Estrogens are important endocrine regulators of skeletal growth and maintenance in both females and ...
The incidence of cardiovascular diseases was significantly increased in postmenopausal women. The pr...
Abstract Background The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection again...
Much is known about estrogen action in experimental animal models and in human physiology. This arti...
Although 17\u3b2-estradiol (E2) anti-inflammatory activity has been well described, very little is k...
AbstractEstrogen receptor-related receptor-α (ERRα) is an orphan member of the nuclear receptor supe...
Estrogen plays several important physiological and pathological functions in not only reproductive s...
Sex steroids, such as Estrogen, play important roles in physiological and pathological processes, in...