Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses
- Seregin, Sergei V
- Babkina, Irina N
- Nesterov, Andrei E
- Sinyakov, Aleksander N
- Shchelkunov, Sergei N
Publication date
March 1996
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
13Abstract
AbstractTo study specific properties of the human gamma-interferon (γ-IFN) receptor-like proteins of the highly virulent and low virulent strains of variola (smallpox) virus (VAR) recombinant plasmids determining synthesis of these proteins in E. coli cells have been constructed. The recombinant viral γ-IFN receptor-like proteins have been found to have high interferon-neutralising activity with regards to human γ-IFN but not murine γ-IFN and human α-IFN. The variola major and variola minor proteins under study do not differ in the efficiency of human γ-IFN antiviral activity inhibition
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