Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb)
Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members ...
The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food upt...
We have recently reported the first naturally occurring missense mutations in the leptin receptor (L...
Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally c...
SummaryLeptin regulates energy homeostasis, fertility, and the immune system, making it an important...
Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight...
© 2016 British Society for NeuroendocrinologyThe adipocyte-derived hormone leptin regulates appetite...
Obesity is a chronic pathology with multi-factorial aetiology, characterized by extreme body weight ...
Body weight control is a mechanism finely regulated by several hormonal, metabolic, and nervous path...
The body weight control is a mechanism thinly regulated by several hormonal, metabolic, and nervous ...
Leptin plays a central role in the control of body weight and energy homeostasis, but is a pleiotrop...
AbstractLeptin (OB) exerts weight-reducing effects in mice. The structure of the receptor for this f...
The adipocyte-derived cytokine leptin acts as a metabolic switch, connecting the body's metabolism t...
AbstractThe adipocyte-derived hormone leptin signals the status of body energy stores by activating ...
SummaryLeptin activates its cognate receptor (LR) to regulate body weight and metabolically costly p...
Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members ...
The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food upt...
We have recently reported the first naturally occurring missense mutations in the leptin receptor (L...
Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally c...
SummaryLeptin regulates energy homeostasis, fertility, and the immune system, making it an important...
Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight...
© 2016 British Society for NeuroendocrinologyThe adipocyte-derived hormone leptin regulates appetite...
Obesity is a chronic pathology with multi-factorial aetiology, characterized by extreme body weight ...
Body weight control is a mechanism finely regulated by several hormonal, metabolic, and nervous path...
The body weight control is a mechanism thinly regulated by several hormonal, metabolic, and nervous ...
Leptin plays a central role in the control of body weight and energy homeostasis, but is a pleiotrop...
AbstractLeptin (OB) exerts weight-reducing effects in mice. The structure of the receptor for this f...
The adipocyte-derived cytokine leptin acts as a metabolic switch, connecting the body's metabolism t...
AbstractThe adipocyte-derived hormone leptin signals the status of body energy stores by activating ...
SummaryLeptin activates its cognate receptor (LR) to regulate body weight and metabolically costly p...
Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members ...
The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food upt...
We have recently reported the first naturally occurring missense mutations in the leptin receptor (L...
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