Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reported single-molecule analyses of pre-mRNA splicing, confirming transcription-coupled splicing of constitutive introns but finding off-site and delayed splicing of alternative introns. The results raise the question of whether kinetics distinguishes constitutive from regulated splicing
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairin...
In eukaryotes the coding regions of most genes are interrupted by introns that must be removed by sp...
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. Afte...
Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reporte...
SummaryRemoval of introns from pre-messenger RNAs (pre-mRNAs) via splicing provides a versatile mean...
© 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commo...
Deep sequencing of embryonic stem cell RNA revealed many specific internal introns that are signific...
Alternative splicing accounts for much of the complexity in higher eukaryotes. Thus, its regulation ...
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reactio...
SummaryIntrons are removed from pre-mRNAs during transcription while the pre-mRNA is still tethered ...
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape...
When eucaryotic genes are expressed, they are transcribed into pre-mRNAs (precursormRNAs) that need ...
Cellular function and physiology are largely established through regulated gene expression. The firs...
Metazoan genes have recently been found to contain a novel class of introns that display non-canonic...
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape...
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairin...
In eukaryotes the coding regions of most genes are interrupted by introns that must be removed by sp...
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. Afte...
Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reporte...
SummaryRemoval of introns from pre-messenger RNAs (pre-mRNAs) via splicing provides a versatile mean...
© 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commo...
Deep sequencing of embryonic stem cell RNA revealed many specific internal introns that are signific...
Alternative splicing accounts for much of the complexity in higher eukaryotes. Thus, its regulation ...
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reactio...
SummaryIntrons are removed from pre-mRNAs during transcription while the pre-mRNA is still tethered ...
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape...
When eucaryotic genes are expressed, they are transcribed into pre-mRNAs (precursormRNAs) that need ...
Cellular function and physiology are largely established through regulated gene expression. The firs...
Metazoan genes have recently been found to contain a novel class of introns that display non-canonic...
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape...
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairin...
In eukaryotes the coding regions of most genes are interrupted by introns that must be removed by sp...
Spliceosomal introns, a hallmark of eukaryotic gene organization, were an unexpected discovery. Afte...
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