Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction
- Gladstone, Rebecca A.
- Jefferies, Johanna M.
- Tocheva, Anna S.
- Beard, Kate R.
- Garley, David
- Chong, Wei Wei
- Bentley, Stephen D.
- Faust, Saul N.
- Clarke, Stuart C.
DOIAbstract
AbstractThe seven-valent pneumococcal conjugate vaccine (PCV7) was added to the UK national immunisation programme in September 2006. PCV13 replaced PCV7 in April 2010. As carriage precedes disease cases this study collected carried pneumococci from children each winter from 2006/7 to 2010/11 over PCV introduction. Conventional microbiology and whole genome sequencing were utilised to characterise pneumococcal strains.Overall prevalence of pneumococcal carriage remained stable. Vaccine serotypes (VT) decreased (p<0.0001) with concomitant increases in non-vaccine serotypes (NVT). In winter 2010/11 only one isolate of PCV7 VT was observed (6B). PCV13 unique VTs decreased between winters immediately preceding and following PCV13 introduction (...
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