SummaryThe retinal anterior homeobox (rax) gene encodes a transcription factor necessary for vertebrate eye development. rax transcription is initiated at the end of gastrulation in Xenopus, and is a key part of the regulatory network specifying anterior neural plate and retina. We describe here a Xenopus tropicalis rax mutant, the first mutant analyzed in detail from a reverse genetic screen. As in other vertebrates, this nonsense mutation results in eyeless animals, and is lethal peri-metamorphosis. Tissue normally fated to form retina in these mutants instead forms tissue with characteristics of diencephalon and telencephalon. This implies that a key role of rax, in addition to defining the eye field, is in preventing alternative forebra...
Background: The genetic cascades underpinning vertebrate early eye morphogenesis are poorly understo...
The aristaless-related gene, Arx, plays a fundamental role in patterning the brain in humans and mic...
AbstractMutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal s...
The paired-like homeobox-containing gene Rx has a critical role in the eye development of several ve...
BackgroundVertebrate eye formation requires coordinated inductive interactions between different emb...
Purpose: The evolutionarily conserved retinal homeobox (Rax) transcription factor is essential for n...
AbstractThe Retinal Homeobox (Rx) gene is essential for vertebrate eye development. Rx function is r...
The paired-class homeobox gene, Rx, is essential for vertebrate eye development. Targeted disruptio...
AbstractTwo alleles of an eyeless mutant, chokh (chk), were identified in ongoing zebrafish F3 mutag...
Vertebrate eye formation is a complex process which involves early specification of the prospective ...
AbstractThe possibility that mechanisms of retinal determination may be similar between vertebrates ...
Rax is one of the key transcription factors crucial for vertebrate eye development. In this study, w...
AbstractDespite the importance of the retinal pigment epithelium (RPE) for vision, the molecular pro...
AbstractZebrafish retinal homeobox genes rx1 and rx2 are expressed exclusively in the optic primordi...
ABSTRACT Vertebrate eye formation is a complex process which involves early specification of the pro...
Background: The genetic cascades underpinning vertebrate early eye morphogenesis are poorly understo...
The aristaless-related gene, Arx, plays a fundamental role in patterning the brain in humans and mic...
AbstractMutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal s...
The paired-like homeobox-containing gene Rx has a critical role in the eye development of several ve...
BackgroundVertebrate eye formation requires coordinated inductive interactions between different emb...
Purpose: The evolutionarily conserved retinal homeobox (Rax) transcription factor is essential for n...
AbstractThe Retinal Homeobox (Rx) gene is essential for vertebrate eye development. Rx function is r...
The paired-class homeobox gene, Rx, is essential for vertebrate eye development. Targeted disruptio...
AbstractTwo alleles of an eyeless mutant, chokh (chk), were identified in ongoing zebrafish F3 mutag...
Vertebrate eye formation is a complex process which involves early specification of the prospective ...
AbstractThe possibility that mechanisms of retinal determination may be similar between vertebrates ...
Rax is one of the key transcription factors crucial for vertebrate eye development. In this study, w...
AbstractDespite the importance of the retinal pigment epithelium (RPE) for vision, the molecular pro...
AbstractZebrafish retinal homeobox genes rx1 and rx2 are expressed exclusively in the optic primordi...
ABSTRACT Vertebrate eye formation is a complex process which involves early specification of the pro...
Background: The genetic cascades underpinning vertebrate early eye morphogenesis are poorly understo...
The aristaless-related gene, Arx, plays a fundamental role in patterning the brain in humans and mic...
AbstractMutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal s...