AbstractCyclins are regulatory subunits that bind to and activate catalytic Cdks. Cyclin E associates with Cdk2 to mediate the G1/S transition of the cell cycle. Cyclin E is overexpressed in breast, lung, skin, gastrointestinal, cervical, and ovarian cancers. Its overexpression correlates with poor patient prognosis and is involved in the etiology of breast cancer. We have been studying how cyclin E is normally downregulated during development in order to determine if disruption of similar mechanisms could either contribute to its overexpression in cancer, or be exploited to decrease its expression. In Xenopus laevis embryos, cyclin E protein level is high and constant until its abrupt destabilization by an undefined mechanism after the 12t...
SummaryUbiquitination of murine cyclin E is triggered by phosphorylation on threonine 393. Cyclin ET...
The Eg1 gene in Xenopus laevis is related in sequence to the cdc2+ gene. We show here that the Eg1 g...
International audienceCyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the...
AbstractCyclins are regulatory subunits that bind to and activate catalytic Cdks. Cyclin E associate...
Cyclin-Cdk complexes positively regulate cell cycle progression. Cyclins are regulatory subunits tha...
Cyclins and cyclin dependent kinases (Cdk) are key regulators of the cell cycle. Cyclin E binds to a...
AbstractMitotic cyclins are key cell-cycle regulators that are relatively stable through most of the...
AbstractDuringXenopusdevelopment, the early cell cycles consist of rapid oscillations between DNA sy...
AbstractBackground: The destruction of cyclin B is required for exit from mitosis, and is mediated b...
AbstractIn mammalian cells, E-type cyclins (E1 and E2) are generally believed to be required for ent...
AbstractWe report here the first extensivein vivostudy of cell cycle regulation in theXenopusembryo....
Functional clam cyclin A and B proteins have been produced using a baculovirus expression system. Bo...
Cell division and differentiation are largely incompatible but the molecular links between the two p...
International audienceActivation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphory...
AbstractIn higher eukaryotes, Cdk2 kinase plays an essential role in regulating the G1–S transition....
SummaryUbiquitination of murine cyclin E is triggered by phosphorylation on threonine 393. Cyclin ET...
The Eg1 gene in Xenopus laevis is related in sequence to the cdc2+ gene. We show here that the Eg1 g...
International audienceCyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the...
AbstractCyclins are regulatory subunits that bind to and activate catalytic Cdks. Cyclin E associate...
Cyclin-Cdk complexes positively regulate cell cycle progression. Cyclins are regulatory subunits tha...
Cyclins and cyclin dependent kinases (Cdk) are key regulators of the cell cycle. Cyclin E binds to a...
AbstractMitotic cyclins are key cell-cycle regulators that are relatively stable through most of the...
AbstractDuringXenopusdevelopment, the early cell cycles consist of rapid oscillations between DNA sy...
AbstractBackground: The destruction of cyclin B is required for exit from mitosis, and is mediated b...
AbstractIn mammalian cells, E-type cyclins (E1 and E2) are generally believed to be required for ent...
AbstractWe report here the first extensivein vivostudy of cell cycle regulation in theXenopusembryo....
Functional clam cyclin A and B proteins have been produced using a baculovirus expression system. Bo...
Cell division and differentiation are largely incompatible but the molecular links between the two p...
International audienceActivation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphory...
AbstractIn higher eukaryotes, Cdk2 kinase plays an essential role in regulating the G1–S transition....
SummaryUbiquitination of murine cyclin E is triggered by phosphorylation on threonine 393. Cyclin ET...
The Eg1 gene in Xenopus laevis is related in sequence to the cdc2+ gene. We show here that the Eg1 g...
International audienceCyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the...