Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled
- Li, Yi-Ju
- Scott, William K.
- Hedges, Dale J.
- Zhang, Fengyu
- Gaskell, P. Craig
- Nance, Martha A.
- Watts, Ray L.
- Hubble, Jean P.
- Koller, William C.
- Pahwa, Rajesh
- Stern, Matthew B.
- Hiner, Bradley C.
- Jankovic, Joseph
- Allen, Fred H.
- Goetz, Christopher G.
- Mastaglia, Frank
- Stajich, Jeffrey M.
- Gibson, Rachel A.
- Middleton, Lefkos T.
- Saunders, Ann M.
- Scott, Burton L.
- Small, Gary W.
- Nicodemus, Kristin K.
- Reed, Allison D.
- Schmechel, Donald E.
- Welsh-Bohmer, Kathleen A.
- Conneally, P. Michael
- Roses, Allen D.
- Gilbert, John R.
- Vance, Jeffery M.
- Haines, Jonathan L.
- Pericak-Vance, Margaret A.
DOIAbstract
To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%–60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene ...
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