AbstractThe niche surrounding stem cells regulate their fate during homeostasis and after injury or infection. The 3D organoid assay has been widely used to study stem cells behavior based on its capacity to evaluate self-renewal, differentiation and the effect of various medium supplements, drugs and co-culture with supportive cells. We established an assay to study both lung and trachea stem cells in vitro. We characterized their proliferation and differentiation spectrum at baseline then evaluated the effect of co-culturing with fibroblasts and endothelial cells and/or treating with several biologically relevant substances as possible contributors to their niche. We found that lung epithelial (but not tracheal basal) stem cells require c...
The ideal cell type to regenerate an acutely injured or chronically diseased lung would be a stem ce...
Several acute and chronic inflammatory pathologies of the lung are accompanied by structural modific...
Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithe...
AbstractThe niche surrounding stem cells regulate their fate during homeostasis and after injury or ...
Throughout life adult animals crucially depend on stem cell populations to maintain and repair their...
Lung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and normal...
Lung epithelial cell damage and dysfunctional repair play a role in the development of lung disease....
SummaryLung stem cells are instructed to produce lineage-specific progeny through unknown factors in...
Abstract Fueled by the promise of regenerative medicine, currently there is unprecedented interest i...
Recent studies have identified epithelial stem and progenitor cell populations of the lung. We are j...
Stem cells are believed to be crucial players in tumor development. There is much interest in identi...
Lung diseases are devastating conditions and ranked as one of the top five causes of mortality world...
In recent years significant progress has been witnessed in the identification of stem cells, which h...
In response to recurrent exposure to environmental insults such as allergens, pollution, irritants, ...
International audienceLungs have a complex structure composed of different cell types that form appr...
The ideal cell type to regenerate an acutely injured or chronically diseased lung would be a stem ce...
Several acute and chronic inflammatory pathologies of the lung are accompanied by structural modific...
Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithe...
AbstractThe niche surrounding stem cells regulate their fate during homeostasis and after injury or ...
Throughout life adult animals crucially depend on stem cell populations to maintain and repair their...
Lung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and normal...
Lung epithelial cell damage and dysfunctional repair play a role in the development of lung disease....
SummaryLung stem cells are instructed to produce lineage-specific progeny through unknown factors in...
Abstract Fueled by the promise of regenerative medicine, currently there is unprecedented interest i...
Recent studies have identified epithelial stem and progenitor cell populations of the lung. We are j...
Stem cells are believed to be crucial players in tumor development. There is much interest in identi...
Lung diseases are devastating conditions and ranked as one of the top five causes of mortality world...
In recent years significant progress has been witnessed in the identification of stem cells, which h...
In response to recurrent exposure to environmental insults such as allergens, pollution, irritants, ...
International audienceLungs have a complex structure composed of different cell types that form appr...
The ideal cell type to regenerate an acutely injured or chronically diseased lung would be a stem ce...
Several acute and chronic inflammatory pathologies of the lung are accompanied by structural modific...
Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithe...