Unholy Matrimony: Aurora A and N-Myc as Malignant Partners in Neuroblastoma
- Maris, John M.
Publication date
January 2009
DOI Publisher
Elsevier Inc. ISSN
1535-6108 Citation count (estimate)
12Abstract
Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora A's potential as a therapeutic target
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