AbstractThe T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-aff...
Post-thymic naïve T cells constitute a key cellular arm of adaptive immunity, with a well-known char...
The ability of T cells to identify foreign antigens and mount an efficient immune response while lim...
AbstractThe T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports di...
SummaryIn the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of develo...
AbstractCD4+CD8+ thymocyte differentiation requires TCR signaling induced by self-peptide/MHC ligand...
SummaryDeveloping T cells express diverse antigen receptors whose specificities are not prematched t...
SummaryDuring selection of the T cell repertoire, the immune system navigates the subtle distinction...
Naive T cells spend most of their time scanning the surface of dendritic cells (DCs), indicating tha...
SummaryThe degree of T cell self-reactivity considered dangerous by the immune system, thereby requi...
T cell homeostasis must be tightly controlled. In this issue of Immunity, Cho et al. (2010) describe...
In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of developing T ...
In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of developing T ...
T cells initiate and regulate adaptive immune responses that can clear infections. To do this, they ...
Continuous contact with self-major histocompatibility complex (MHC) ligands is essential for surviva...
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-aff...
Post-thymic naïve T cells constitute a key cellular arm of adaptive immunity, with a well-known char...
The ability of T cells to identify foreign antigens and mount an efficient immune response while lim...
AbstractThe T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports di...
SummaryIn the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of develo...
AbstractCD4+CD8+ thymocyte differentiation requires TCR signaling induced by self-peptide/MHC ligand...
SummaryDeveloping T cells express diverse antigen receptors whose specificities are not prematched t...
SummaryDuring selection of the T cell repertoire, the immune system navigates the subtle distinction...
Naive T cells spend most of their time scanning the surface of dendritic cells (DCs), indicating tha...
SummaryThe degree of T cell self-reactivity considered dangerous by the immune system, thereby requi...
T cell homeostasis must be tightly controlled. In this issue of Immunity, Cho et al. (2010) describe...
In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of developing T ...
In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of developing T ...
T cells initiate and regulate adaptive immune responses that can clear infections. To do this, they ...
Continuous contact with self-major histocompatibility complex (MHC) ligands is essential for surviva...
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-aff...
Post-thymic naïve T cells constitute a key cellular arm of adaptive immunity, with a well-known char...
The ability of T cells to identify foreign antigens and mount an efficient immune response while lim...
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