A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway
- Bridoux, Lucie
- Etique, Nicolas
- Lambert, Elise
- Thevenard, Jessica
- Sowa, Marie-Line
- Belloy, Nicolas
- Dauchez, Manuel
- Martiny, Laurent
- Charpentier, Emmanuelle
Publication date
May 2013
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
7Abstract
AbstractTIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival
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