Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells
- Lally, Christine
- Healy, Edel
- Ryan, Michael P.
Publication date
October 1999
DOI Publisher
International Society of Nephrology. Published by Elsevier Inc. ISSN
0085-2538 Citation count (estimate)
34Abstract
Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells. We studied the effects of cyclosporine A (CsA) on the proliferation of LLC-PK1 proximal tubule epithelial cells. DNA damage was found to be an early event in CsA nephrotoxicity and could be a sensitive indicator of CsA injury in renal epithelial cells. Cell cycle arrest induced by CsA was coincident with elevated p53 levels. It is possible that trans-activating p21 may mediate the halting of the cell cycle through the CsA-induced accumulation of p53
Add to ORKG