Deuterium NMR study of head-group deuterated phosphatidylserine in pure and binary phospholipid bilayers Interactions with monovalent cations Na+ and Li+

AbstractHead-group deuterated 1,2-dimyristoyl-sn-glycero-3-phosphorylserine (DMPS) was synthesized. 2H NMR spectra reflect the ionic strength-dependent polymorphism of DMPS aqueous dispersions. Results obtained with pure DMPS and mixed bilayers with phosphatidylcholine or phosphatidylethanolamine at various NaCl or LiCl concentrations indicate that interactions with Na+ and Li+ have very different effects upon the head-group quadrupole splittings