Human skin exhibits exquisite site-specific morphologies and functions. How are these site-specific differences specified during development, maintained in adult homeostasis, and potentially perturbed by disease processes? Here, we review progress in understanding the anatomic patterning of fibroblasts, a major constituent cell type of the dermis and key participant in epithelial–mesenchymal interactions. The gene expression programs of human fibroblasts largely reflect the superimposition of three gene expression profiles that demarcate the fibroblast's position relative to three developmental axes. The HOX family of homeodomain transcription factors is implicated in specifying site-specific transcriptional programs. The use of gene, tilin...
The dermis contains two distinct layers: the papillary and the reticular layers. In vitro cultures o...
This work was funded by the Wellcome Trust (F.M.W., A.C.F.-S.), the Medical Research Council (MRC) ...
The formation of hair follicles, a landmark of mammals, requires complex mesenchymal–epithelial inte...
Human skin exhibits exquisite site-specific morphologies and functions. How are these site-specific ...
SummaryThe murine epidermis with its hair follicles represents an invaluable model system for tissue...
Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role in m...
Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangemen...
The evidence for fibroblast heterogeneity is continuously increasing, and recent work has shed some ...
Skin architecture and function depend on diverse populations of epidermal cells and dermal fibroblas...
There are multiple fibroblast populations found in adult skin dermis. Within this thesis I will dis...
SummaryDefining the unique molecular features of progenitors and their niche requires a genome-wide,...
AbstractAdvances in cell culture methods, multidisciplinary research, clinical need to replace lost ...
The skin plays a critical role in securing homeostasis in the mammalian body. Its epidermis forms a...
BACKGROUND: The skin protects mammals from insults, infection and dehydration and enables thermoregu...
Fibroblasts are ubiquitous mesenchymal cells with many vital functions during development, tissue re...
The dermis contains two distinct layers: the papillary and the reticular layers. In vitro cultures o...
This work was funded by the Wellcome Trust (F.M.W., A.C.F.-S.), the Medical Research Council (MRC) ...
The formation of hair follicles, a landmark of mammals, requires complex mesenchymal–epithelial inte...
Human skin exhibits exquisite site-specific morphologies and functions. How are these site-specific ...
SummaryThe murine epidermis with its hair follicles represents an invaluable model system for tissue...
Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role in m...
Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangemen...
The evidence for fibroblast heterogeneity is continuously increasing, and recent work has shed some ...
Skin architecture and function depend on diverse populations of epidermal cells and dermal fibroblas...
There are multiple fibroblast populations found in adult skin dermis. Within this thesis I will dis...
SummaryDefining the unique molecular features of progenitors and their niche requires a genome-wide,...
AbstractAdvances in cell culture methods, multidisciplinary research, clinical need to replace lost ...
The skin plays a critical role in securing homeostasis in the mammalian body. Its epidermis forms a...
BACKGROUND: The skin protects mammals from insults, infection and dehydration and enables thermoregu...
Fibroblasts are ubiquitous mesenchymal cells with many vital functions during development, tissue re...
The dermis contains two distinct layers: the papillary and the reticular layers. In vitro cultures o...
This work was funded by the Wellcome Trust (F.M.W., A.C.F.-S.), the Medical Research Council (MRC) ...
The formation of hair follicles, a landmark of mammals, requires complex mesenchymal–epithelial inte...