Negative influence of RasG on chemoattractant-induced ERK2 phosphorylation in Dictyostelium
- Kosaka, Chiya
- Khosla, Meenal
- Weeks, Gerald
- Pears, Catherine
Publication date
March 1998
DOI Publisher
Published by Elsevier B.V. ISSN
0167-4889Abstract
AbstractThe Dictyostelium ERK2 protein is transiently activated when cells are treated with the chemotactic agents cAMP or folic acid. Activating phosphorylation is markedly inhibited in strains overexpressing the constitutively activated RasG protein. This is in marked contrast to mammalian cells where the highly related mitogen-activated protein kinases (MAPKs) are stimulated by Ras activation
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