ObjectiveEye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. We aimed to confirm these results in a phase III study and investigated a potential clinical benefit on visual acuity (VA), quality of life (QoL), and need for transplantation.DesignMulticenter, double-masked, randomized, placebo-controlled phase III study.ParticipantsAnalysis of 69 patients with keratitis-related progressive corneal neovascularization randomized to aganirsen (34 patients) or placebo (35 patients). Patients applied aganirsen eye drops (86 μg/day/eye) or placebo twice daily for 90 days and were followed up to day 180.Main Outcome Meas...
Cornea is the transparent layer in front of the eye that does not contain blood vessels. Among eye d...
PURPOSE: To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sun...
Background: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most...
OBJECTIVE: Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrat...
ObjectiveEye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-...
Purpose. To evaluate the safety and efficacy of topical pazopanib in the treatment of corneal neova...
Purpose. To investigate whether corneal graft survival could be improved by topical or subconjuncti...
Purpose To examine the effect of topical ranibizumab on clinically stable corneal neovascularizatio...
AbstractCorneal neovascularization (NV), the excessive ingrowth of blood vessels from conjunctiva in...
The cornea has the unique feature of being normally avascular except for small loops which invade t...
Corneal transplantation is among the most successful solid organ transplants. However, despite low r...
Background: This study evaluated the effects of topically applied axitinib, a tyrosine kinase inhibi...
Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the corne...
Objectives To study the safety and efficacy of topical bevacizumab in the treatment of corneal neov...
The rabbit corneal pocket assay is one of the most frequently used systems for the study of angiogen...
Cornea is the transparent layer in front of the eye that does not contain blood vessels. Among eye d...
PURPOSE: To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sun...
Background: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most...
OBJECTIVE: Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrat...
ObjectiveEye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-...
Purpose. To evaluate the safety and efficacy of topical pazopanib in the treatment of corneal neova...
Purpose. To investigate whether corneal graft survival could be improved by topical or subconjuncti...
Purpose To examine the effect of topical ranibizumab on clinically stable corneal neovascularizatio...
AbstractCorneal neovascularization (NV), the excessive ingrowth of blood vessels from conjunctiva in...
The cornea has the unique feature of being normally avascular except for small loops which invade t...
Corneal transplantation is among the most successful solid organ transplants. However, despite low r...
Background: This study evaluated the effects of topically applied axitinib, a tyrosine kinase inhibi...
Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the corne...
Objectives To study the safety and efficacy of topical bevacizumab in the treatment of corneal neov...
The rabbit corneal pocket assay is one of the most frequently used systems for the study of angiogen...
Cornea is the transparent layer in front of the eye that does not contain blood vessels. Among eye d...
PURPOSE: To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sun...
Background: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most...