AbstractOral naltrexone reduces heavy drinking, but is less consistent as an abstinence promoter, whereas once-monthly extended-release naltrexone (XR-NTX) also maintains abstinence. The present study sought to determine if alcohol cue reactivity is attenuated by XR-NTX. Twenty-eight detoxified alcohol-dependent adult male and female volunteers received a single i.m. injection of either XR-NTX or placebo under double-blind conditions. An fMRI/cue reactivity procedure was conducted immediately before and two weeks after injection. At baseline, alcohol-related visual and olfactory cues elicited significant increases in orbital and cingulate gyri, inferior frontal and middle frontal gyri. Subsequently, brain activation was significantly altere...
The ability of alcohol-related cues to promote craving can be attenuated independently by giving the...
Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consumm...
Previously, we found that distinct brain areas predict individual selection bias in decisions betwee...
AbstractOral naltrexone reduces heavy drinking, but is less consistent as an abstinence promoter, wh...
During the first weeks of abstinence, alcohol craving in patients may increase or “incubate.” We hyp...
There is a concerted research effort to investigate brain mechanisms underlying addiction processes ...
Context—Medication treatment of alcoholism is presently not particularly robust. Neuroimaging techni...
Naltrexone is an opioid receptor antagonist used in the management of alcohol dependence. Although t...
Identifying key neural substrates in addiction disorders for targeted drug development remains a maj...
Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in al...
The opioid receptor antagonist naltrexone (NTX) reduces goal-directed alcohol drinking in rats presu...
There is a concerted research effort to investigate brain mechanisms underlying addiction processes ...
Relapse to alcohol addiction after prolonged withdrawal periods is a major problem in the treatment ...
Identifying key neural substrates in addiction disorders for targeted drug development remains a maj...
Naltrexone (NTX) is an opioid antagonist indicated for the treatment of alcoholism, which is not uni...
The ability of alcohol-related cues to promote craving can be attenuated independently by giving the...
Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consumm...
Previously, we found that distinct brain areas predict individual selection bias in decisions betwee...
AbstractOral naltrexone reduces heavy drinking, but is less consistent as an abstinence promoter, wh...
During the first weeks of abstinence, alcohol craving in patients may increase or “incubate.” We hyp...
There is a concerted research effort to investigate brain mechanisms underlying addiction processes ...
Context—Medication treatment of alcoholism is presently not particularly robust. Neuroimaging techni...
Naltrexone is an opioid receptor antagonist used in the management of alcohol dependence. Although t...
Identifying key neural substrates in addiction disorders for targeted drug development remains a maj...
Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in al...
The opioid receptor antagonist naltrexone (NTX) reduces goal-directed alcohol drinking in rats presu...
There is a concerted research effort to investigate brain mechanisms underlying addiction processes ...
Relapse to alcohol addiction after prolonged withdrawal periods is a major problem in the treatment ...
Identifying key neural substrates in addiction disorders for targeted drug development remains a maj...
Naltrexone (NTX) is an opioid antagonist indicated for the treatment of alcoholism, which is not uni...
The ability of alcohol-related cues to promote craving can be attenuated independently by giving the...
Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consumm...
Previously, we found that distinct brain areas predict individual selection bias in decisions betwee...