Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Classical immunosuppressants like cyclophosphamide give excellent results in human lupus nephritis. However, they augment malignancies and viral infections. Here we investigated the effect of the new immunosuppressant agent, mycophenolate mofetil (MMF), in New Zealand Black x New Zealand White (NZBxW) F1 hybrid mice, a model of genetically determined immune complex disease that mimics systemic lupus in humans. MMF has a selective antiproliferative effect on T- and B-lymphocytes, inhibits antibody formation and blocks the glyco-sylation of lymphocyte glycoproteins involved in the adhesion of leukocytes to endothelial cells. Two groups of NZBxW mic...
Improved patient survival following lupus nephritis with the institution of corticosteroids, immunos...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is characterized by autoant...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...
Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Clas...
Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis....
Mycophenolate mofetil (MMF), an immunosuppressive drug commonly used in organ transplantation, is in...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...
Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly affects women. The effect of...
Progression to chronic renal failure varies between patients with lupus nephritis. We compared the e...
AbstractBackgroundFew studies have evaluated the effects and precise molecular mechanism of mycophen...
AbstractBackgroundFew studies have evaluated the effects and precise molecular mechanism of mycophen...
Mycophenolate mofetil (MMF), an immunosuppressivedrug commonly used in organ transplanta-tion, is in...
The optimal treatment of severe lupus nephritis is unclear. Regimens consisting of steroid and cyclo...
Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. As an alter...
Background: Few studies have evaluated the effects and precise molecular mechanism of mycophenolate ...
Improved patient survival following lupus nephritis with the institution of corticosteroids, immunos...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is characterized by autoant...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...
Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Clas...
Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis....
Mycophenolate mofetil (MMF), an immunosuppressive drug commonly used in organ transplantation, is in...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...
Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly affects women. The effect of...
Progression to chronic renal failure varies between patients with lupus nephritis. We compared the e...
AbstractBackgroundFew studies have evaluated the effects and precise molecular mechanism of mycophen...
AbstractBackgroundFew studies have evaluated the effects and precise molecular mechanism of mycophen...
Mycophenolate mofetil (MMF), an immunosuppressivedrug commonly used in organ transplanta-tion, is in...
The optimal treatment of severe lupus nephritis is unclear. Regimens consisting of steroid and cyclo...
Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. As an alter...
Background: Few studies have evaluated the effects and precise molecular mechanism of mycophenolate ...
Improved patient survival following lupus nephritis with the institution of corticosteroids, immunos...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is characterized by autoant...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...