Synthesis, antimicrobial evaluation and QSAR studies of p-coumaric acid derivatives

AbstractA series of p-coumaric acid derivatives (1–36) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were evaluated in vitro for their antimicrobial activity against different Gram positive and Gram negative bacterial and fungal strains by the tube dilution method. Results of antimicrobial screening indicated that compound 17 was the most active antimicrobial agent (pMICam=1.73μM/mL). The results of QSAR studies demonstrated that antibacterial, antifungal and overall antimicrobial activities of synthesized p-coumaric acid derivatives were governed by the electronic parameter, electronic energy (Ee) and topological parameters first order molecular connectivity index (1χ) and Wiener index (W)