Underhill and colleagues (Shimada et al., 2010) provide evidence for an intriguing link between the activity of lysozyme in the phagosome and activation of the Nlrp3 inflammasome, a cytosolic regulator of inflammation and cytokine production. The authors show that resistance to lysozyme allows Staphylococcus aureus to evade Nlrp3 activation
Innate immune recognition of microbial components serves as a cornerstone in mediating an effective ...
Inflammasomes are cytosolic protein complexes that serve as platforms for the recruitment and activa...
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range...
Underhill and colleagues (Shimada et al., 2010) provide evidence for an intriguing link between the ...
SummaryIL-1β produced by phagocytes is important for protection against the mucosal pathogen Staphyl...
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critica...
SummaryInflammasomes are molecular platforms activated upon cellular infection or stress that trigge...
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host...
The inflammasomes are emerging as key regulators of the innate immune response as they response to c...
The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the proc...
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host...
Macrophages undergo profound metabolic reprogramming upon sensing infectious and sterile stimuli. Th...
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as m...
The inflammasome is a multiprotein complex that mediates caspase-1 activation with subsequent matura...
Interactions with the host immune system alters S. aureus response to therapeutic antibiotics. We fi...
Innate immune recognition of microbial components serves as a cornerstone in mediating an effective ...
Inflammasomes are cytosolic protein complexes that serve as platforms for the recruitment and activa...
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range...
Underhill and colleagues (Shimada et al., 2010) provide evidence for an intriguing link between the ...
SummaryIL-1β produced by phagocytes is important for protection against the mucosal pathogen Staphyl...
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critica...
SummaryInflammasomes are molecular platforms activated upon cellular infection or stress that trigge...
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host...
The inflammasomes are emerging as key regulators of the innate immune response as they response to c...
The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the proc...
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host...
Macrophages undergo profound metabolic reprogramming upon sensing infectious and sterile stimuli. Th...
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as m...
The inflammasome is a multiprotein complex that mediates caspase-1 activation with subsequent matura...
Interactions with the host immune system alters S. aureus response to therapeutic antibiotics. We fi...
Innate immune recognition of microbial components serves as a cornerstone in mediating an effective ...
Inflammasomes are cytosolic protein complexes that serve as platforms for the recruitment and activa...
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range...
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